3-Benzyloxy-5-(Trifluoromethyl)Pyridine → 5-(Trifluoromethyl)pyridin-3-ol

Participants

Role	Name	HCID	Charge
Reactant	3-Benzyloxy-5-(Trifluoromethyl)Pyridine	HCID 21851825	—
Catalyst	Palladium	HCID 23938	—
Solvent	Methanol	HCID 887	—
Product	5-(Trifluoromethyl)pyridin-3-ol	HCID 22989707	38.8%

Reaction Conditions

Temperature	50 °C

Reaction Steps

To a solution of 3-(benzyloxy)-5-(trifluoromethyl)pyridine (10 g, 39.5 mmol) in methanol (100 mL) was added Pd/C (0.500 g, 4.70 mmol). The reaction mixture was stirred at 50° C. under H2 (55 psi) for 24 h, filtered and concentrated under reduce pressure to afford the crude product (2.5 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09051325B2
Source dataset	uspto-grants-2015_06
ORD ID	ord-5bc1abbe719149f9a067e0bc49e33ad9
Source note	uspto-grants-2015_06