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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2171376Generated: October 25, 2026

7-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one → 7-((4-((6-chloropyridin-3-yl)oxy)-3,5-difluorobenzyl)oxy)-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

https://huagongshe.com/reaction/2171376

Reaction equation

Participants

RoleNameHCIDCharge
Reactant7-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-oneHCID 86728345—
Reactant(4-((6-Chloropyridin-3-yl)oxy)-3,5-difluorophenyl)methanolHCID 86728352—
Product7-((4-((6-chloropyridin-3-yl)oxy)-3,5-difluorobenzyl)oxy)-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-oneHCID 86728351—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E9 starting from (4-((6-chloropyridin-3-yl)oxy)-3,5-difluorophenyl)methanol and 7-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09051325B2
Source datasetuspto-grants-2015_06
ORD IDord-7b89c720a9d348f1b62e4bd39524c6b9
Source noteuspto-grants-2015_06