5-(Hydroxymethyl)-2-(3-(trifluoromethyl)phenoxy)benzonitrile → HCID 86728355, compound

HRID 2171379Notes

Reaction equation

HRID 2171379 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)=[C:7]([CH:10]=1)[C:8]#[N:9].Cl[C:23]1[CH:24]=[C:25]2[N:32]([CH:33]3[CH2:35][CH2:34]3)[CH2:31][CH2:30][N:26]2[C:27](=[O:29])[N:28]=1>>[CH:33]1([N:32]2[C:25]3[N:26]([C:27](=[O:29])[N:28]=[C:23]([O:1][CH2:2][C:3]4[CH:4]=[CH:5][C:6]([O:11][C:12]5[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=5)=[C:7]([CH:10]=4)[C:8]#[N:9])[CH:24]=3)[CH2:30][CH2:31]2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 668254365-(Hydroxymethyl)-2-(3-(trifluoromethyl)phenoxy)benzonitrileHCID 86728325HCID 86728325, compound

Product 1

HCID 86728355HCID 86728355, compound

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from 5-(hydroxymethyl)-2-(3-(trifluoromethyl)phenoxy)benzonitrile and 7-chloro-1-cyclopropyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-dab27e769ed043fd86a7f7966104daaa
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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