4-(2-Fluoro-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrile → (S)-4-(4-(((1,2-dimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)ox-y)methyl)-2-fluorophenoxy)-2-(trifluoromethyl)benzonitrile

HRID 2171380Notes

Reaction equation

HRID 2171380 reaction equation
[F:1][C:2]1[CH:20]=[C:19]([CH2:21][OH:22])[CH:18]=[CH:17][C:3]=1[O:4][C:5]1[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:15])[F:14])[CH:6]=1.Cl[C:24]1[CH:25]=[C:26]2[N:33]([CH3:34])[C@@H:32]([CH3:35])[CH2:31][N:27]2[C:28](=[O:30])[N:29]=1>>[CH3:34][N:33]1[C:26]2[N:27]([C:28](=[O:30])[N:29]=[C:24]([O:22][CH2:21][C:19]3[CH:18]=[CH:17][C:3]([O:4][C:5]4[CH:12]=[CH:11][C:8]([C:9]#[N:10])=[C:7]([C:13]([F:16])([F:14])[F:15])[CH:6]=4)=[C:2]([F:1])[CH:20]=3)[CH:25]=2)[CH2:31][C@@H:32]1[CH3:35]

Participants

3

Reactant 2

HCID 712397254-(2-Fluoro-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrileHCID 86728322(S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 86728356(S)-4-(4-(((1,2-dimethyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)ox-y)methyl)-2-fluorophenoxy)-2-(trifluoromethyl)benzonitrile

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from 4-(2-fluoro-4-(hydroxymethyl)phenoxy)-2-(trifluoromethyl)benzonitrile and (S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-8084fb5af99149f2af6bac324e05cc9b
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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