HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-5-(hydroxymethyl)benzonitrile → (S)-3-fluoro-5-(((2-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-5-(hydroxymethyl)benzonitrile | HCID 68662252 | — |
| Reactant | (S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate | HCID 86728347 | — |
| Product | (S)-3-fluoro-5-(((2-methyl-5-oxo-1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidin-7-yl)oxy)methyl)benzonitrile | HCID 86728371 | — |
Reaction Steps
The title compound was prepared by a procedure similar to that described for E1 starting from 3-fluoro-5-(hydroxymethyl)benzonitrile and (S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09051325B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-8b60f680a1c740a9b4c4003ed4a581c1 |
| Source note | uspto-grants-2015_06 |