Sodium hydride → HCID 86728376, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl 7-((3,5-difluoro-4-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzyl)oxy)-2,2-dimethyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate (95 mg, 0.167 mmol) in tetrahydrofuran (THF) (2 mL) stirred at 0° C. was added NaH (20.05 mg, 0.501 mmol). The reaction mixture was stirred for 18 h at 20° C., quenched with water and concentrated in vacuo. Purification via preparative TLC with ethyl acetate afforded the title product.

Provenance & Evidence