HCID 71236687, compound → HCID 86728394, compound

HRID 2171414Notes

Reaction equation

HRID 2171414 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][C:8]=2[C:9]#[N:10])=[CH:4][CH:3]=1.Cl[C:20]1[CH:21]=[C:22]2[N:29]([CH3:30])[C@@H:28]([CH3:31])[CH2:27][N:23]2[C:24](=[O:26])[N:25]=1>>[CH3:30][N:29]1[C:22]2[N:23]([C:24](=[O:26])[N:25]=[C:20]([O:16][CH2:15][C:12]3[CH:13]=[CH:14][C:7]([O:6][C:5]4[CH:17]=[CH:18][C:2]([F:1])=[CH:3][CH:4]=4)=[C:8]([CH:11]=3)[C:9]#[N:10])[CH:21]=2)[CH2:27][C@@H:28]1[CH3:31]

Participants

3

Reactant 2

HCID 71236687HCID 71236687, compoundHCID 86728322(S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 86728394HCID 86728394, compound

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from 2-(4-fluorophenoxy)-5-(hydroxymethyl)benzonitrile and (S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-de1fd5244b874087a4eb8cd90bc2afe1
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

Loading…