7-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one → HCID 86728402, compound

HRID 2171421Notes

Reaction equation

HRID 2171421 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:17][OH:18])[CH:5]=[C:6]([F:16])[C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]([F:15])=[CH:13][CH:14]=1.Cl[C:20]1[CH:21]=[C:22]2[N:29]([CH3:30])[C:28]([CH3:32])([CH3:31])[CH2:27][N:23]2[C:24](=[O:26])[N:25]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([F:16])[C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]([F:15])=[CH:13][CH:14]=1)[CH2:17][O:18][C:20]1[CH:21]=[C:22]2[N:29]([CH3:30])[C:28]([CH3:32])([CH3:31])[CH2:27][N:23]2[C:24](=[O:26])[N:25]=1

Participants

3

Reactant 2

HCID 867283457-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-oneHCID 86728403HCID 86728403, compound

Product 1

HCID 86728402HCID 86728402, compound

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from (3,5-difluoro-4-((6-fluoropyridin-3-yl)oxy)phenyl)methanol and 7-chloro-1,2,2-trimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-11c611395c354bd3a89544d1fba21a41
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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