3,5-Difluorobenzyl alcohol → HCID 86728418, compound

HRID 2171435Notes

Reaction equation

HRID 2171435 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[CH:5]=[C:6]([F:8])[CH:7]=1.C(OC([N:18]1[C:26]2[N:21]([C:22](=[O:28])[N:23]=[C:24](Cl)[CH:25]=2)[CH2:20][C@@H:19]1[CH3:29])=O)(C)(C)C>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([F:8])[CH:7]=1)[CH2:9][O:10][C:24]1[CH:25]=[C:26]2[NH:18][C@@H:19]([CH3:29])[CH2:20][N:21]2[C:22](=[O:28])[N:23]=1

Participants

3

Reactant 2

HCID 5227213,5-Difluorobenzyl alcoholHCID 86728347(S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Product 1

HCID 86728418HCID 86728418, compound

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from (3,5-difluorophenyl)methanol and (S)-tert-butyl-7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-928821ad43474044bdef1b0918ee0a36
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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