HCID 71240313, compound → HCID 86728421, compound

HRID 2171438Notes

Reaction equation

HRID 2171438 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][C:12]=2[F:19])=[CH:6][C:3]=1[C:4]#[N:5].Cl[C:21]1[CH:22]=[C:23]2[N:30]([CH3:31])[C@@H:29]([CH3:32])[CH2:28][N:24]2[C:25](=[O:27])[N:26]=1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][O:18][C:21]3[CH:22]=[C:23]4[N:30]([CH3:31])[C@@H:29]([CH3:32])[CH2:28][N:24]4[C:25](=[O:27])[N:26]=3)=[CH:13][C:12]=2[F:19])=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 71240313HCID 71240313, compoundHCID 86728322(S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 86728421HCID 86728421, compound

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from 2-chloro-5-(2-fluoro-4-(hydroxymethyl)phenoxy)benzonitrile and (S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-9adc03d7fdd64b1fae49f54e0546d579
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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