(3-Fluoro-4-(4-fluorophenoxy)phenyl)methanol → (S)-7-((3-fluoro-4-(4-fluorophenoxy)benzyl)oxy)-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 2171441Notes

Reaction equation

HRID 2171441 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:16][OH:17])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1.Cl[C:19]1[CH:20]=[C:21]2[N:28]([CH3:29])[C@@H:27]([CH3:30])[CH2:26][N:22]2[C:23](=[O:25])[N:24]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)[CH2:16][O:17][C:19]1[CH:20]=[C:21]2[N:28]([CH3:29])[C@@H:27]([CH3:30])[CH2:26][N:22]2[C:23](=[O:25])[N:24]=1

Participants

3

Reactant 2

HCID 28946101(3-Fluoro-4-(4-fluorophenoxy)phenyl)methanolHCID 86728322(S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 86728424(S)-7-((3-fluoro-4-(4-fluorophenoxy)benzyl)oxy)-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from (3-fluoro-4-(4-fluorophenoxy)phenyl)methanol and (S)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-d0b7fb0ae4ed4e7f9e2de4ed7ddb57dc
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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