HCID 66825874, compound → HCID 86728430, compound

HRID 2171445Notes

Reaction equation

HRID 2171445 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:19][OH:20])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:10]=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[N:13][CH:14]=1.C(OC([N:28]1[C:36]2[N:31]([C:32](=[O:38])[N:33]=[C:34](Cl)[CH:35]=2)[CH2:30][C:29]1([CH3:40])[CH3:39])=O)(C)(C)C>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:14]=[N:13][C:12]([C:15]([F:17])([F:18])[F:16])=[N:11][CH:10]=1)[CH2:19][O:20][C:34]1[CH:35]=[C:36]2[NH:28][C:29]([CH3:40])([CH3:39])[CH2:30][N:31]2[C:32](=[O:38])[N:33]=1

Participants

3

Reactant 2

HCID 66825874HCID 66825874, compoundHCID 86728374tert-butyl 7-chloro-2,2-dimethyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Product 1

HCID 86728430HCID 86728430, compound

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from (3-fluoro-4-((2-(trifluoromethyl)pyrimidin-5-yl)oxy)phenyl)methanol and tert-buty-7-chloro-2,2-dimethyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-3ad83e6f055a4ebe84233e1c94129c23
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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