3,4-Difluorobenzyl alcohol → (R)-7-((3,4-difluorobenzyl)oxy)-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

HRID 2171447Notes

Reaction equation

HRID 2171447 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][OH:10])[CH:5]=[CH:6][C:7]=1[F:8].Cl[C:12]1[CH:13]=[C:14]2[N:21]([CH3:22])[C@H:20]([CH3:23])[CH2:19][N:15]2[C:16](=[O:18])[N:17]=1>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[F:8])[CH2:9][O:10][C:12]1[CH:13]=[C:14]2[N:21]([CH3:22])[C@H:20]([CH3:23])[CH2:19][N:15]2[C:16](=[O:18])[N:17]=1

Participants

3

Reactant 2

HCID 5228333,4-Difluorobenzyl alcoholHCID 86728369(R)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 86728432(R)-7-((3,4-difluorobenzyl)oxy)-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from (3,4-difluorophenyl)methanol and (R)-7-chloro-1,2-dimethyl-2,3-dihydroimidazo-[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-cdc67135901e405997b6412de87bd0f3
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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