3-(Hydroxymethyl)benzonitrile → HCID 86728435, compound

HRID 2171450Notes

Reaction equation

HRID 2171450 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=1)[C:6]#[N:7].Cl[C:12]1[CH:13]=[C:14]2[N:21](C(OC(C)(C)C)=O)[C@@H:20]([CH3:29])[CH2:19][N:15]2[C:16](=[O:18])[N:17]=1>>[CH3:29][C@H:20]1[CH2:19][N:15]2[C:16](=[O:18])[N:17]=[C:12]([O:1][CH2:2][C:3]3[CH:4]=[C:5]([CH:8]=[CH:9][CH:10]=3)[C:6]#[N:7])[CH:13]=[C:14]2[NH:21]1

Participants

3

Reactant 2

HCID 27346773-(Hydroxymethyl)benzonitrileHCID 86728347(S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate

Product 1

HCID 86728435HCID 86728435, compound

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from 3-(hydroxymethyl)benzonitrile and (S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-d8495c3e170449b0ad79ee7bffdd31a1
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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