HCID 67958464, compound → HCID 86728445, compound

HRID 2171459Notes

Reaction equation

HRID 2171459 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[O:5][C:6]1[CH:13]=[CH:12][C:11]([CH2:14][OH:15])=[CH:10][C:7]=1[C:8]#[N:9].Cl[C:21]1[CH:22]=[C:23]2[N:30]([CH:31]3[CH2:33][CH2:32]3)[CH2:29][CH2:28][N:24]2[C:25](=[O:27])[N:26]=1>>[CH:31]1([N:30]2[C:23]3[N:24]([C:25](=[O:27])[N:26]=[C:21]([O:15][CH2:14][C:11]4[CH:12]=[CH:13][C:6]([O:5][C:4]5[CH:16]=[CH:17][C:18]([F:19])=[C:2]([F:1])[CH:3]=5)=[C:7]([CH:10]=4)[C:8]#[N:9])[CH:22]=3)[CH2:28][CH2:29]2)[CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 67958464HCID 67958464, compoundHCID 86728325HCID 86728325, compound

Product 1

HCID 86728445HCID 86728445, compound

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from 2-(3,4-difluorophenoxy)-5-(hydroxymethyl)benzonitrile and 7-chloro-1-cyclopropyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-fd155daa84474f20a08885764b576188
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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