2-Fluoro-5-(hydroxymethyl)benzonitrile → HCID 86728447, compound

HRID 2171461Notes

Reaction equation

HRID 2171461 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7]([CH2:10][OH:11])=[CH:6][C:3]=1[C:4]#[N:5].Cl[C:13]1[CH:14]=[C:15]2[N:22]([CH3:23])[CH:21]([CH3:24])[CH2:20][N:16]2[C:17](=[O:19])[N:18]=1>>[CH3:23][N:22]1[C:15]2[N:16]([C:17](=[O:19])[N:18]=[C:13]([O:11][CH2:10][C:7]3[CH:8]=[CH:9][C:2]([F:1])=[C:3]([CH:6]=3)[C:4]#[N:5])[CH:14]=2)[CH2:20][CH:21]1[CH3:24]

Participants

3

Reactant 2

HCID 27739342-Fluoro-5-(hydroxymethyl)benzonitrileHCID 867283147-chloro-1,2-dimethyl-2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one

Product 1

HCID 86728447HCID 86728447, compound

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from 2-fluoro-5-(hydroxymethyl)benzonitrile and 7-chloro-1,2-dimethyl-2,3-dihydroimi-dazo[1,2-c]pyrimidin-5(1H)-one.

Sources & evidence

ORD record
ord-1f25a1cc71e545728391eba8bac8f7ad
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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