(S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate → HCID 86728454, compound

HRID 2171468Notes

Reaction equation

HRID 2171468 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:20][OH:21])[CH:5]=[C:6]([F:19])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=1.C(OC([N:29]1[C:37]2[N:32]([C:33](=[O:39])[N:34]=[C:35](Cl)[CH:36]=2)[CH2:31][C@@H:30]1[CH3:40])=O)(C)(C)C>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([F:19])[C:7]=1[O:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([C:15]([F:16])([F:17])[F:18])[CH:10]=1)[CH2:20][O:21][C:35]1[CH:36]=[C:37]2[NH:29][C@@H:30]([CH3:40])[CH2:31][N:32]2[C:33](=[O:39])[N:34]=1

Participants

3

Reactant 2

HCID 86728347(S)-tert-butyl 7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylateHCID 86728396HCID 86728396, compound

Product 1

HCID 86728454HCID 86728454, compound

Procedure

The title compound was prepared by a procedure similar to that described for E9 starting from (3,5-difluoro-4-((2-(trifluoromethyl)pyridin-4-yl)oxy)phenyl)methanol and (S)-tert-butyl-7-chloro-2-methyl-5-oxo-2,3-dihydroimidazo[1,2-c]pyrimidine-1(5H)-carboxylate.

Sources & evidence

ORD record
ord-1b0e8e4a0d8f40c2b9318a22a916f65e
Source dataset
uspto-grants-2015_06
Patent number
US09051325B2

Reaction notes

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