Ethanolamine → HCID 59312917, compound

HRID 2171502Notes

Reaction equation

HRID 2171502 reaction equation
Cl[C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][C:12]=2[Cl:18])[N:3]=1.[NH2:19][CH2:20][CH2:21][OH:22]>CS(C)=O>[Cl:18][C:12]1[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=1[C:4]1[N:3]=[C:2]([NH:19][CH2:20][CH2:21][OH:22])[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 59312932HCID 59312932, compound

Product 1

HCID 59312917HCID 59312917, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

2-{[7-(2,4-Dichlorophenyl)imidazo[1,2-c]pyrimidin-5-yl]amino}ethanol (Example 49A) is prepared in analogy to Example 36A from 5-chloro-7-(2,4-dichlorophenyl)imidazo[1,2-c]-pyrimidine (Example 6A) (200 mg, 0.7 mmol) and 2-aminoethanol (82 mg, 1.3 mmol) in DMSO (80° C., 4 h). Removal of the solvent results in a crude product which is precipitated from dichloromethane. The product is filtered off with suction and dried. 216 mg (99% of theory) of product are obtained as a solid.

Workup

  1. customRemoval of the solvent

Sources & evidence

ORD record
ord-52280d459f0148bcb30b6f222f7dccb5
Source dataset
uspto-grants-2015_06
Patent number
US09051323B2

Reaction notes

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