4-Pyrimidinamine, 2,6-dichloro- → HCID 59313150, compound

HRID 2171509Notes

Reaction equation

HRID 2171509 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[C:4]([Cl:9])[N:3]=1.[NH2:10][CH2:11][CH2:12][NH:13][C:14]1[N:19]=[CH:18][C:17]([C:20]#[N:21])=[CH:16][CH:15]=1>C(#N)C>[NH2:8][C:6]1[CH:5]=[C:4]([Cl:9])[N:3]=[C:2]([NH:10][CH2:11][CH2:12][NH:13][C:14]2[N:19]=[CH:18][C:17]([C:20]#[N:21])=[CH:16][CH:15]=2)[N:7]=1

Participants

4

Reactant 2

HCID 823874-Pyrimidinamine, 2,6-dichloro-HCID 113694056-[(2-Aminoethyl)amino]pyridine-3-carbonitrile

Product 1

HCID 59313150HCID 59313150, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

10.3 g (63 mmol) of 2,6-dichloropyrimidine-4-amine and 10.22 g (63 mmol) of 6-[(2-aminoethyl)amino]pyridine-3-carbonitrile are dissolved in 164 ml acetonitrile and heated under reflux conditions for 24 h. After cooling, the major amount of the precipitated product is filtered off with suction. 11.9 g (50% of theory) of the product are obtained as a solid.

Workup

  1. temperatureheated under reflux conditions for 24 h
  2. temperatureAfter cooling
  3. filtrationthe major amount of the precipitated product is filtered off with suction
  4. custom11.9 g (50% of theory) of the product are obtained as a solid

Sources & evidence

ORD record
ord-5748c532b90c400b8633b735c9e027d6
Source dataset
uspto-grants-2015_06
Patent number
US09051323B2

Reaction notes

Loading…