反应详情

温度

60 °C

A solution of 484 mg (2.4 mmol) of 3-bromo-1,1,1-trifluoropropan-2-one in 12 ml of DMSO is added dropwise to the crude mixture from Example 72A while cooling in ice, and the mixture is then heated at 60° C. for 1 h. The crude mixture is poured into ice-water and extracted three times with ethyl acetate. After the combined organic phases have been dried, the solvent is completely removed and the residue is purified by subsequent purification by preparative HPLC. 640 mg (67% of theory) of the product are obtained as a solid.

1. temperaturewhile cooling in ice
2. extractionextracted three times with ethyl acetate
3. customAfter the combined organic phases have been dried
4. customthe solvent is completely removed
5. customthe residue is purified by subsequent purification by preparative HPLC
6. custom640 mg (67% of theory) of the product are obtained as a solid