Potassium Hydroxide → HCID 178480838, compound

HRID 2171520Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13](SCC)[N:12]2[CH:18]=[C:19]([CH2:21][N:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[N:20]=[C:11]2[CH:10]=1.[OH-:29].[K+]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:14]=[C:13]([OH:29])[N:12]2[CH:18]=[C:19]([CH2:21][N:22]3[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]3)[N:20]=[C:11]2[CH:10]=1

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 59312975HCID 59312975, compound

Product 1

HCID 178480838HCID 178480838, compound

Procedure

In analogy to Example 10A, 500 mg (97% of theory) of the product are obtained from 675 mg (1.31 mmol) of 7-(2,4-dichlorophenyl)-5-(ethylsulphanyl)-2-[(4-methylpiperazin-1-yl)methyl]-imidazo[1,2-c]pyrimidine (Example 93A) by heating in methanolic potassium hydroxide solution.

Sources & evidence

ORD record: ord-cb2f125219fd4e0791edc21f73bd2035
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09051323B2

Reaction notes

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