Phosphorus oxychloride → HCID 59313080, compound

Participants

Reaction Steps

103 mg (0.267 mmol) of 7-(2,4-dichlorophenyl)-2-(morpholin-4-ylmethyl)imidazo[1,2-c]-pyrimidin-5-ol (Example 93A) are introduced in 5 ml (53.64 mmol) of phosphoryl chloride and heated at the reflux temperature for 3 h. The mixture is allowed to cool and is added cautiously to an ice/water mixture. The precipitate which separates out is filtered off. Drying under high vacuum results in 105 mg (99% of theory) of the product.

Provenance & Evidence