Potassium Hydroxide → HCID 178483297, compound

HRID 2171523Notes

Reaction equation

HRID 2171523 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](SC)[N:5]2[CH:10]=[C:11]([CH2:13][N:14]([CH3:16])[CH3:15])[N:12]=[C:4]2[CH:3]=1.[OH-:17].[K+]>>[Cl:1][C:2]1[N:7]=[C:6]([OH:17])[N:5]2[CH:10]=[C:11]([CH2:13][N:14]([CH3:16])[CH3:15])[N:12]=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 59313071HCID 59313071, compound

Product 1

HCID 178483297HCID 178483297, compound

Procedure

In analogy to Example 33A, 150 mg (98% of theory) of the product are obtained from 150 mg (0.58 mmol) of 1-[7-chloro-5-(methylsulphanyl)imidazo[1,2-c]pyrimidin-2-yl]-N,N-dimethylmethanamine (Example 97A) by heating in methanolic potassium hydroxide solution.

Sources & evidence

ORD record
ord-8fdddb4ca2434832adcae285bfe911e1
Source dataset
uspto-grants-2015_06
Patent number
US09051323B2

Reaction notes

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