Potassium Hydroxide → HCID 178437473, compound

HRID 2171525Notes

Reaction equation

HRID 2171525 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](SC)[N:5]2[N:10]=[C:11]([CH2:13][CH3:14])[N:12]=[C:4]2[CH:3]=1.[OH-:15].[K+]>>[Cl:1][C:2]1[N:7]=[C:6]([OH:15])[N:5]2[N:10]=[C:11]([CH2:13][CH3:14])[N:12]=[C:4]2[CH:3]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 59313139HCID 59313139, compound

Product 1

HCID 178437473HCID 178437473, compound

Procedure

In analogy to Example 33A, 242 mg (99% of theory) of the product are obtained from 280 mg (1.22 mmol) of 7-chloro-2-ethyl-5-(methylsulphanyl) [1,2,4]triazolo[1,5-c]pyrimidine (Example 101A) by heating in methanolic potassium hydroxide solution.

Sources & evidence

ORD record
ord-f20dee4625d84c30b456f2ac4152ede3
Source dataset
uspto-grants-2015_06
Patent number
US09051323B2

Reaction notes

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