N-BOC-ethylenediamine → HCID 59313094, compound

HRID 2171536Notes

Reaction equation

HRID 2171536 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=[C:11](Cl)[N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:20]([NH:27][CH2:28][CH2:29][NH2:30])([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21]>>[C:1]([O:5][C:6]([NH:8][C:9]1[C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=[C:11]([NH:30][CH2:29][CH2:28][NH:27][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[N:10]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 53419545Methyl 2-[(tert-butoxycarbonyl)amino]-6-chloropyridine-3-carboxylate

Product 1

HCID 59313094HCID 59313094, compound

Procedure

The compound is prepared from 650 mg (2.3 mmol) of methyl 2-[(tert-butoxycarbonyl)amino]-6-chloropyridine-3-carboxylate (Example 118A) and 363 mg (2.3 mmol) of N-Boc-ethylenediamine as described in Example 114A. 500 mg (50% of theory) of the product are obtained as a solid.

Workup

  1. custom500 mg (50% of theory) of the product are obtained as a solid

Sources & evidence

ORD record
ord-0044e62a91444b16bca3be048a526771
Source dataset
uspto-grants-2015_06
Patent number
US09051323B2

Reaction notes

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