HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Pyrrolidino)phenylboronic acid → 3-Nitro-N6-(2-{[7-(3-pyrrolidin-1-ylphenyl)[1,2,4]triazolo[1,5-c]pyrimidin-5-yl]amino}-ethyl)pyridine-2,6-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Pyrrolidino)phenylboronic acid | HCID 4192669 | — |
| Reactant | N6-{2-[(7-Chloro[1,2,4]triazolo[1,5-c]pyrimidin-5-yl)amino]ethyl}-3-nitropyridine-2,6-diamine | HCID 59312901 | — |
| Product | 3-Nitro-N6-(2-{[7-(3-pyrrolidin-1-ylphenyl)[1,2,4]triazolo[1,5-c]pyrimidin-5-yl]amino}-ethyl)pyridine-2,6-diamine | HCID 59313095 | — |
Reaction Steps
In analogy to the procedure described for Example 94, 17.5 mg (28% of theory) of the product are obtained as a solid starting from 50 mg (0.133 mmol) of N6-{2-[(7-chloro[1,2,4]triazolo-[1,5-c]pyrimidin-5-yl)amino]ethyl}-3-nitropyridine-2,6-diamine (Example 55A) by coupling with 25.3 mg (0.13 mmol) of (3-pyrrolidin-1-ylphenyl)boronic acid and subsequent purification by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09051323B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-b7712140aa034b2cb30fada011f9fdb4 |
| Source note | uspto-grants-2015_06 |