反应详情

温度

0 °C

To a suspension of N-(3-chloro-2-methylphenyl)acetamide (35 g, 0.19 mol) in 350 mL of glacial AcOH cooled to 0° C. was added bromine (29.5 mL, 0.57 mol) dropwise. The ice bath was removed and the solution was stirred for 24 h and then poured into ice water with stirring. The solid was then filtered and dried to give the title compound (45 g, 90%) which was used for the next step without any further purification.

1. customThe ice bath was removed
2. additionpoured into ice water
3. stirringwith stirring
4. filtrationThe solid was then filtered
5. customdried