HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-(3-Chloro-4-cyano-2-methylphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-(4-Bromo-3-chloro-2-methylphenyl)acetamide | HCID 86376 | — |
| Reactant | HCID 178418260 | HCID 178418260 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(3-Chloro-4-cyano-2-methylphenyl)acetamide | HCID 58932655 | 70.5% |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
A suspension of N-(4-bromo-3-chloro-2-methylphenyl)acetamide (45 g, 0.17 mol) and copper cyanide (34 g, 0.34 mol) in DMF (450 mL) was heated to 150° C. for 24 h. The suspension was cooled, poured into water with stirring. The solid was filtered and dried to give 25 g (70%) of the title compound which was used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09051326B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-6bcb8fbebd424b099bc6b67732f5cd89 |
| Source note | uspto-grants-2015_06 |