Methanol → HCID 15381006, compound

HRID 2171593Notes

Reaction equation

HRID 2171593 reaction equation
[OH:1][C@H:2]1[CH2:6][CH2:5][NH:4][C@@H:3]1[C:7]([OH:9])=[O:8].[CH3:10]O>>[OH:1][C@H:2]1[CH2:6][CH2:5][NH:4][C@@H:3]1[C:7]([O:9][CH3:10])=[O:8]

Participants

3

Reactant 2

HCID 887MethanolHCID 440575trans-3-hydroxy-L-proline

Product 1

HCID 15381006HCID 15381006, compound

Procedure

To a stirred solution of trans-3-hydroxy-L-proline (15 g, 0.114 moles) in methanol (200 mL) was added borontrifluoride diethyl ether (42 mL, 0.343 moles) and the reaction mixture was refluxed for 48 h. Once the starting material had disappeared (monitored by TLC) the reaction mixture was concentrated to get the title compound which was used in the next step without further purification.

Workup

  1. temperaturethe reaction mixture was refluxed for 48 h
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-0a4b5c6c0b6b405ab9308148379f761c
Source dataset
uspto-grants-2015_06
Patent number
US09051326B2

Reaction notes

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