反应详情

To a solution of (2S,3S)-methyl 3-hydroxy-1-nitrosopyrrolidine-2-carboxylate (13 g, 0.0742 moles) in DCM (150 mL) at room temperature were added imidazole (15.2 g, 0.224 moles) and TBDMS-Cl (22.5 g, 0.149 moles) and the mixture was stirred at room temperature for 3 h. The reaction mixture was diluted with DCM and washed with water, brine, dried over Na2SO4 and concentrated. Purification by column chromatography over silica gel using 10% EtOAc in hexane as a solvent provided the title compound.

1. washwashed with water, brine
2. dry with materialdried over Na2SO4
3. concentrationconcentrated
4. customPurification by column chromatography over silica gel using 10% EtOAc in hexane as a solvent