Tetrabutylammonium Fluoride → HCID 71239141, compound

Participants

Reaction Steps

To a solution of 4-((3S,3aR,4S)-4-(tert-butyldimethylsilyloxy)-3-(tetrahydro-2H-pyran-2-yloxy)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-2-chloro-3-methylbenzonitrile (120 mg, 0.245 mmol) in THF (2 mL) at 0° C. was added tetrabutylammonium fluoride (0.49 mL, 0.490 mmol, 1M solution in THF) and the reaction mixture was stirred at room temperature for 3 h. Once the starting material had disappeared (monitored by TLC), it was diluted with ethyl acetate and the organic layer was washed with water, brine, dried over Na2SO4 and concentrated. Purification of crude by column chromatography over silica gel using 30% EtOAc in hexane provided the title compound.

Provenance & Evidence