p-Toluenesulfonic acid → HCID 71239369, compound

Participants

Reaction Steps

To a stirred solution of 2-chloro-4-((3S,3aS,4R)-4-hydroxy-3-(tetrahydro-2H-pyran-2-yloxy)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-3-methylbenzonitrile (30 mg, 0.088 mmol) in methanol (1 mL) was added p-toluenesulfonic acid (20 mg, 0.1058 mmol) and the reaction mixture was stirred at room temperature for overnight. Methanol was evaporated from reaction mixture and extracted with EtOAc. Organic layer was washed with water, brine, dried over Na2SO4 and concentrated. Purification by column chromatography over silica gel using 3% MeOH in DCM provided the title compound.

Provenance & Evidence