p-Toluenesulfonic acid → HCID 71241133, compound

Participants

Reaction Steps

To a stirred solution of 4-((3S,3aR,4S)-4-((tert-butyldimethylsilyl)oxy)-3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-2-chloro-3-methylbenzonitrile (160 mg, 0.299 mmol) in methanol (5 mL) at room temperature was added p-toluenesulphonic acid and stirred for 1 h. Once the starting material had disappeared (monitored by TLC) methanol was removed from the reaction mixture and then extracted with EtOAc. Organic layer was washed with water, brine, dried over Na2SO4 and concentrated. Crude product was purified by column chromatography using 15% in ethylacetate in hexane as solvent.

Provenance & Evidence