Tetrabutylammonium Fluoride → HCID 89396982, compound

Participants

Reaction Steps

To a stirred solution of 4-((3S,3aR,4S)-4-((tert-butyldimethylsilyl)oxy)-3-(2-fluoroethoxy)-3a,4,5,6-tetrahydro-3H-pyrrolo[1,2-b]pyrazol-2-yl)-2-chloro-3-methylbenzonitrile (30 mg, 0.0664 mmol) in THF (4 mL) at 0° C. was added TBAF (0.13 mL, 0.132 mmol, 1M Solution in THF) and stirred for 1 h at room temperature. Once the starting material had disappeared (monitored by TLC), reaction mixture was diluted with ethyl acetate. Organic layer was washed with water, brine, dried over Na2SO4 and concentrated. Crude product was purified by preparative TLC method using 2% methanol in DCM as eluent.

Provenance & Evidence