HCID 68308566, compound → HCID 62309410, compound

HRID 2171656Notes

Reaction equation

HRID 2171656 reaction equation
[O:1]=[C:2]1[N:7]([CH2:8][C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)[CH2:6][CH2:5][N:4](C(OCC2C=CC=CC=2)=O)[CH2:3]1.[H][H]>[C].[Pd].CCO>[N:11]1[CH:12]=[CH:13][CH:14]=[C:9]([CH2:8][N:7]2[CH2:6][CH2:5][NH:4][CH2:3][C:2]2=[O:1])[CH:10]=1

Participants

5

Reactant 2

HCID 68308566HCID 68308566, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 62309410HCID 62309410, compoundYield 93.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Benzyl 3-oxo-4-(pyridin-3-ylmethyl)piperazine-1-carboxylate (345 mg) was mixed with EtOH (7 ml), and 10% palladium carbon (70 mg) was added thereto under argon atmosphere to change the atmosphere to hydrogen atmosphere, followed by stirring at room temperature overnight. The reaction mixture was filtered using Celite as a filtration adjuvant, and the filtrate was concentrated under reduced pressure to obtain 1-(pyridin-3-ylmethyl)piperazin-2-one (190 mg).

Workup

  1. additionwas added
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d87489f721e842ffb7e76d3fa1a24d87
Source dataset
uspto-grants-2015_06
Patent number
US09051283B2

Reaction notes

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