HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 4-(Chloromethyl)-2,6-dimethylpyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,6-Dimethyl-4-(hydroxymethyl)pyridine | HCID 3825077 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(Chloromethyl)-2,6-dimethylpyridine hydrochloride | HCID 23001645 | — |
Reaction Steps
(2,6-Dimethylpyridin-4-yl)methanol (457 mg) was mixed with DCE (8 ml), and thionyl chloride (0.6 ml) and DMF (19 mg) were added thereto, followed by stirring at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure to obtain 4-(chloromethyl)-2,6-dimethylpyridine hydrochloride (567 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09051283B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-fdd973e5c9704b20b4c08ee03c4b50b7 |
| Source note | uspto-grants-2015_06 |