反应详情

温度

60 °C

To a suspension of 5-methoxy-1,1-dimethyl-indan (2.16 g, 12.25 mmol) (prepared following the procedures described in U.S. Pat. Appl. Publ., 2006100460) in water (120 ml), NBS (2.2 g, 12.3 mmol) was added. The reaction mixture was heated to 60° C. while stirring. Concentrated H2SO4 (1.3 ml, 40% aq. solution) was then added and stirring was continued for 5 hours. The reaction mixture was cooled to rt. The mixture was extracted with diethyl ether three times. The combined organic extract was washed with brine and dried (Na2SO4). Silica gel chromatography (ethyl acetate/heptane) provided 2.78 g (89%) of the title compound.

1. customprepared
2. stirringstirring
3. temperatureThe reaction mixture was cooled to rt
4. extractionThe mixture was extracted with diethyl ether three times
5. extractionThe combined organic extract
6. washwas washed with brine
7. dry with materialdried (Na2SO4)