反应详情

To a vigorously stirred solution of sodium hydrogen cyanamide (0.21 g, 3.21 mmol) in methanol (10 mL) was added slowly (S)-2-(1,1-dimethyl-indan-5-yloxymethyl)-oxirane (0.57 g, 3.21 mmol). The reaction mixture was stirred at room temperature overnight after which the reaction mixture was concentrated. Anhydrous diethyl ether (50 mL) was added. The resulting white precipitate was filtered through Celite and the filtrate concentrated. The residue was purified by flash chromatography (silica, 7N NH3 in methanol/methylene chloride) to give 0.41 g (49%) of 5-(1,1-dimethyl-indan-5-yloxymethyl)-4,5-dihydro-oxazol-2-ylamine.

1. concentrationwas concentrated
2. additionAnhydrous diethyl ether (50 mL) was added
3. filtrationThe resulting white precipitate was filtered through Celite
4. concentrationthe filtrate concentrated
5. customThe residue was purified by flash chromatography (silica, 7N NH3 in methanol/methylene chloride)