反应详情

To a mixture of ethyl 6-(4,4-dimethylcyclohexyl)-2-methylthieno[2,3-d]pyrimidine-4-carboxylate (1.0 g) and EtOH (10 mL) was added a 1 M aqueous NaOH solution (3.9 mL) under ice-cooling, followed by stirring at the same temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, and 1 M hydrochloric acid was added thereto, followed by stirring for 30 minutes. The precipitate was collected by filtration, washed with water and then with hexane, dried by flowing air, and then dried under reduced pressure to obtain 6-(4,4-dimethylcyclohexyl)-2-methylthieno[2,3-d]pyrimidine-4-carboxylic acid (900 mg).

1. temperaturecooling
2. concentrationThe reaction mixture was concentrated under reduced pressure, and 1 M hydrochloric acid
3. additionwas added
4. stirringby stirring for 30 minutes
5. filtrationThe precipitate was collected by filtration
6. washwashed with water
7. dry with materialwith hexane, dried
8. customdried under reduced pressure