Dimethylamine → HCID 57659559, compound

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Reaction Steps

To a solution of 4-[5-(4-hydroxymethylfuro[3,2-c]pyridine-2-yl)-[1,2,4]oxadiazole-3-ylmethoxy]piperidine-1-carboxylic acid tert-butyl ester (Example 24, 50 mg, 116 μmol) in THF was added NEt3 (50 mL, 361 μmol), followed by MsCl (15 μL, 194 μmol). After 5 min, of Me2NH (0.3 mL of a 2M solution in THF, 600 μmol) was added and stirring continued for a further 2 h. The mixture was adsorbed onto SiO2 and purified via column chromatography to give the title compound: RT=1.82 min; m/z (ES+)=458.1 [M+H]+.

Provenance & Evidence