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HRID2171911

反应详情

EQUATION

反应方程式

HRID 2171911 反应方程式

REACTANTS

反应物

3
Formic acid 分子结构式
HCID284

Formic acid

CH2O2

Pentanoic acid, 3-[(2-chloro-5-fluoro-4-pyrimidinyl)amino]-4,4-dimethyl-, methyl ester, (3R)- 分子结构式
HCID86714731

Pentanoic acid, 3-[(2-chloro-5-fluoro-4-pyrimidinyl)amino]-4,4-dimethyl-, methyl ester, (3R)-

C12H17ClFN3O2

HCID 178427251 分子结构式
HCID178427251

未命名化合物

PRODUCTS

产物

1
HCID 178445895 分子结构式
HCID178445895

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
Acetonitrile 分子结构式
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

Compound 5 was synthesized in a manner similar to compound 12, starting with compound 6a: 1H NMR (400 MHz, d6-DMSO) δ 12.65 (s, 1H), 9.43 (s, 1H), 9.15 (s, 1H), 8.44 (d, J=4.7 Hz, 1H), 8.41-8.29 (m, 2H), 3.93 (s, 1H), 3.54 (s, 1H), 1.19 (d, J=20.0 Hz, 9H); LCMS Gradient 10-90%, 0.1% formic acid, 5 minutes, C18/ACN, Retention Time=2.70 min, (M+H) 393.32.