tert-Butyl 4-oxopiperidine-1-carboxylate → HCID 57659487, compound

HRID 217193Notes

Reaction equation

HRID 217193 reaction equation
[O:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10]1[N:14]=[C:13]([CH2:15][NH2:16])[O:12][N:11]=1.[C:17]([O:21][C:22]([N:24]1[CH2:29][CH2:28][C:27](=O)[CH2:26][CH2:25]1)=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[C:17]([O:21][C:22]([N:24]1[CH2:29][CH2:28][CH:27]([NH:16][CH2:15][C:13]2[O:12][N:11]=[C:10]([C:2]3[O:1][C:9]4[CH:8]=[CH:7][N:6]=[CH:5][C:4]=4[CH:3]=3)[N:14]=2)[CH2:26][CH2:25]1)=[O:23])([CH3:20])([CH3:18])[CH3:19]

Participants

3

Reactant 2

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 57659419HCID 57659419, compound

Product 1

HCID 57659487HCID 57659487, compound

Procedure

Reductive alkylation of C-(3-furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-methylamine (Preparation 13) with 4-oxo-piperidine-1-carboxylic acid tert-butyl ester, utilising a procedure similar to that described in Example 30, afforded the title compound: RT=2.15 min; m/z (ES+)=400.1 [M+H]+.

Sources & evidence

ORD record
ord-3f91fb392471495aa821e4a82962306a
Source dataset
uspto-grants-2012_06
Patent number
US08193359B2

Reaction notes

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