HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[(4-Fluorophenoxy)methyl]piperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-tert-butyloxycarbonyl4-(p-fluorophenoxymethyl)piperidine | HCID 15512457 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[(4-Fluorophenoxy)methyl]piperidine hydrochloride | HCID 17202828 | 97% |
Reaction Steps
To a cooled solution of tert-butyl 4-[(4-fluorophenoxy)methyl]piperidine-1-carboxylate (538 mg, 1.74 mmol; which may be prepared as described in Step 1) in dichloromethane (11.5 mL) was added dropwise HCl 4N in dioxane (8.5 mL). The solution was warmed to room temperature and stirred for 1 h. The solvent was evaporated under reduced pressure to give the title compound (416 mg, 97%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09051321B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-35cb43aec7c8407c8bacf3dfc83d4a07 |
| Source note | uspto-grants-2015_06 |