Lithium hydroxide, monohydrate → HCID 57659423, compound

Participants

Reaction Steps

A stirred solution of 4-(5-furo[3,2-c]pyridin-2-yl-[1,2,4]oxadiazol-3-ylmethyl)piperidine-1-carboxylic acid 1-methoxycarbonyl-1-methylethyl ester (Example 72, 43 mg, 100 μmol) in THF-H2O (3:1, 2 mL) was treated with LiOH.H2O (9 mg, 220 μmol). After 16 h, the THF was evaporated in vacuo, then the remainder was diluted with H2O (2 mL), before being washed with EtOAc (2×5 mL). The aqueous phase was neutralised with 1 M HCl, then the mixture was extracted with EtOAc (3×10 mL). The combined EtOAc extracts were dried (MgSO4), filtered, and concentrated to furnish the title compound: RT=2.74 min; m/z (ES+)=415.1 [M+H]+.

Provenance & Evidence