Triethylamine → HCID 57659431, compound

Participants

Reaction Steps

i-BuOCOCl (19 μL, 146 μmol) and NEt3 (15 μL, 107 μmol) were added to a stirred solution of 2-(3-piperidin-4-ylmethyl-[1,2,4]oxadiazol-5-yl)furo[3,2-c]pyridine-4-carbonitrile (Preparation 15, 30 mg, 97 μmol) in anhydrous CH2Cl2 (1.5 mL). After 30 min, the reaction mixture was diluted with Et2O (10 mL) and H2O (2 mL). The organic layer was washed with saturated aqueous Na2CO3 (2 mL), H2O (2 mL), and brine (2 mL), before being dried (MgSO4). Filtration, solvent evaporation, and column chromatography (EtOAc) furnished the title compound: RT=3.95 min; m/z (ES+)=410.1 [M+H]+.

Provenance & Evidence