참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1-(Diphenylmethyl)azetidin-3-ol | HCID 330448 | — |
| 촉매 | Acetic Acid | HCID 176 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-(Benzyloxy)-1-(diphenylmethyl)azetidine | HCID 16089448 | 24.3% |
반응 단계
To a solution of 1-diphenylmethylazetidin-3-ol (300 mg, 1.3 mmol) in DMF (2.6 mL) at 0° C. under nitrogen was added NaH (60% in oil, 56 mg, 1.4 mmol). The suspension was stirred for 0.5 h at 0° C. then treated with benzyl bromide (236 μL, 2.0 mmol). The mixture was allowed to warm to room temperature then heated to 80° C. overnight. The reaction mixture was cooled, acetic acid (20 drops) was added and the mixture concentrated under reduced pressure. The crude material was purified on column chromatography (eluent: Pentane/EtOAc, 95/5 to 70/30) to give the product (104 mg, 24%) as an orange oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09051321B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_06 |
|---|
| ORD ID | ord-74fa1549390747118a383b661490a0b4 |
|---|
| 출처 메모 | uspto-grants-2015_06 |
|---|
