HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 57659516, compound → HCID 136189049, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 57659516 | HCID 57659516 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 136189049 | HCID 136189049 | — |
Reaction Steps
A solution of 4-[5-(3-benzyloxyfuro[3,2-c]pyridin-2-yl)-[1,2,4]oxadiazol-3-ylmethyl]-piperidine-1-carboxylic acid tert-butyl ester (Example 120, 200 mg, 500 μmol) and Pd (10% on C, 10 mg) in EtOH (10 mL) was stirred under a H2 atmosphere for 2.5 h. The mixture was diluted with CH2Cl2, to solubilise the product, before being filtered through celite. The filtrate was concentrated to furnish the title compound: RT=2.87 min; m/z (ES+)=401.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08193359B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-f1862b3edfe844b3b31135755e1a0dde |
| Source note | uspto-grants-2012_06 |