Acetic Acid → 2-(3-((1-(3-Methoxypyridin-2-yl)piperidin-4-yl)methyl)-[1,2,4]-oxadiazol-5-yl)furo[3,2-c]pyridine

Participants

Reaction Steps

2-(3-Piperidin-4-ylmethyl-[1,2,4]oxadiazol-5-yl)furo[3,2-c]pyridine (Preparation 12, 50 mg, 0.176 mmol) and 3-methoxy-2-nitropyridine (41 mg, 0.264 mmol) were shaken in DMSO (1 mL) at 100° C. for 20 h. The reaction mixture was allowed to cool to room temperature, before being acidified with AcOH. Purification by RP-HPLC yielded the title compound: RT=4.99 min; m/z (ES+)=392.4 [M+H]+.

Provenance & Evidence