HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2172040Generated: October 31, 2026
Thionyl Chloride → 2-(3-Chloropropyl)thiophene
https://huagongshe.com/reaction/2172040
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(Thiophen-2-yl)propan-1-ol | HCID 13109866 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(3-Chloropropyl)thiophene | HCID 21585204 | — |
Reaction Steps
Thionyl chloride (420 μL, 5.7 mmol) was added to a solution of 3-(2-thienyl)propanol (682.0 mg, 4.8 mmol) in THF (3 mL) at room temperature. The reaction mixture was stirred at 50° C. for 2 hours and then concentrated to dryness to afford the title compound as a brown oil. The product was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09051321B2 |
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| Source dataset | uspto-grants-2015_06 |
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| ORD ID | ord-db099229713c44ada71053b762fedeeb |
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| Source note | uspto-grants-2015_06 |
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