Borane → HCID 66616155, compound

Participants

Reaction Steps

A solution of methyl 3-{1-[4-(2-oxo-pyrrolidin-1-yl)-phenyl]-1H-[1,2,4]triazol-3-yl}-benzoate (278 mg, 0.77 mmol) in THF (5 mL) is treated with borane.tetrahydrofuran complex (3.85 mmol) at ambient temperature. The resulting solution is stirred for 16 h, and quenched by the addition of 6N aq. HCl. After being allowed to stir for 30 min, the mixture is made basic with the addition of 1N aq. sodium hydroxide solution. The mixture is partially evaporated until a precipitate formed, which is collected by filtration, washed with water, and dried under vacuum to afford 226 mg (84%) of methyl 3-[1-(4-pyrrolidin-1-yl-phenyl)-1H-[1,2,4]triazol-3-yl]-benzoate.

Provenance & Evidence